13389-16-7
Chemical Structure
8-Aminoinosine
- CAS No.: 13389-16-7
- Formula:C10H13N5O5
- Molecular Weight:283.24
IUPAC Name: 8-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-6H-purin-6-one
InChIKey: OBCXRIVPFSZZSN-UUOKFMHZSA-N
SMILES: O=C1C2=C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C(N)=N2)NC=N1
Biological Activity: 8-Aminoinosine is a purine nucleoside phosphorylase (PNPase) inhibitor with a Ki value of 35 μM for the human target. 8-Aminoinosine exerts indirect competitive inhibition through two mechanisms: competitive substrate occupancy and metabolic conversion to the PNPase inhibitor (8-Aminohypoxanthine). 8-Aminoinosine induces increased urine output, sodium excretion, and glucose excretion, without altering potassium excretion. 8-Aminoinosine can be used in research related to hypertension, heart failure, and chronic kidney disease[1][2].
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8-Aminoinosine | 8-Aminoinosine is a purine nucleoside phosphorylase (PNPase) inhibitor with a Ki value of 35 μM for the human target. 8-Aminoinosine exerts indirect competitive inhibition through two mechanisms: competitive substrate occupancy and metabolic conversion to the PNPase inhibitor (8-Aminohypoxanthine). 8-Aminoinosine induces increased urine output, sodium excretion, and glucose excretion, without altering potassium excretion. 8-Aminoinosine can be used in research related to hypertension, heart failure, and chronic kidney disease. | |||||||||||||||||||||
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References
- [1]. Jackson EK, et al. 8-Aminoinosine and 8-Aminohypoxanthine Inhibit Purine Nucleoside Phosphorylase and Exert Diuretic and Natriuretic Activity. The Journal of pharmacology and experimental therapeutics. 2022 Aug;382(2):135-148.
- [2]. Jackson EK, et al. 8-Aminopurines in the Cardiovascular and Renal Systems and Beyond. Hypertension (Dallas, Tex. : 1979). 2023 Nov;80(11):2265-2279.
