135-77-3
Chemical Structure
1,2,4-Trimethoxybenzene
- CAS 番号: 135-77-3
- Formula:C9H12O3
- Molecular Weight:168.19
IUPAC Name: 1,2,4-trimethoxybenzene
InChIKey: AGIQIOSHSMJYJP-UHFFFAOYSA-N
SMILES: COC(C(OC)=C1)=CC=C1OC
Biological Activity: 1,2,4-Trimethoxybenzene is an orally active NLRP3 selective inhibitor. 1,2,4-Trimethoxybenzene can markedly suppress Nigericin (HY-127019) or ATP (HY-B2176)-induced NLRP3 inflammasome activation, thus decreasing caspase-1 activation and IL-1β secretion. 1,2,4-Trimethoxybenzene specifically inhibits the activation of NLRP3 inflammasome without affecting absent in melanoma 2 (AIM2) inflammasome activation. 1,2,4-Trimethoxybenzene inhibits oligomerization of the apoptosis-associated speck-like protein containing a CARD (ASC) and protein-protein interaction between NLRP3 and ASC, thus blocking NLRP3 inflammasome assembly. 1,2,4-Trimethoxybenzene can be used for the study of experimental autoimmune encephalomyelitis (EAE), multiple sclerosis, and type 2 diabetes[1][2][3].
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1,2,4-Trimethoxybenzene | 1,2,4-Trimethoxybenzene is an orally active NLRP3 selective inhibitor. 1,2,4-Trimethoxybenzene can markedly suppress Nigericin (HY-127019) or ATP (HY-B2176)-induced NLRP3 inflammasome activation, thus decreasing caspase-1 activation and IL-1β secretion. 1,2,4-Trimethoxybenzene specifically inhibits the activation of NLRP3 inflammasome without affecting absent in melanoma 2 (AIM2) inflammasome activation. 1,2,4-Trimethoxybenzene inhibits oligomerization of the apoptosis-associated speck-like protein containing a CARD (ASC) and protein-protein interaction between NLRP3 and ASC, thus blocking NLRP3 inflammasome assembly. 1,2,4-Trimethoxybenzene can be used for the study of experimental autoimmune encephalomyelitis (EAE), multiple sclerosis, and type 2 diabetes. | |||||||||||||||||||||
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- [1]. Pan RY, et al. 1,2,4-Trimethoxybenzene selectively inhibits NLRP3 inflammasome activation and attenuates experimental autoimmune encephalomyelitis. Acta Pharmacol Sin. 2021 Nov;42(11):1769-1779. doi: 10.1038/s41401-021-00613-8IF: 8.4 Q1 . Epub 2021 Feb 24. Erratum in: Acta Pharmacol Sin. 2022 Feb;43(2):504. [Content Brief]
- [2]. Zhang Y, et al. 1,2,4-Trimethoxybenzene ameliorates depression-like behaviors by inhibiting the activation of NLRP3 inflammasome. Int Immunopharmacol. 2025 Apr 4;151:114361. [Content Brief]
- [3]. Zhong P, et al. 1,2,4-Trimethoxybenzene alleviates cognitive dysfunction in type 2 diabetes model rats by inhibiting NLRP3 inflammasome and restoring gut microbiota disorders. Biochem Pharmacol. 2025 Dec;242(Pt 4):117409. [Content Brief]
Keywords
