135575-42-7
Chemical Structure
Pneumocandin B0
Synonym(s): L-688786
- CAS No.: 135575-42-7
- Formula:C50H80N8O17
- Molecular Weight:1065.21
IUPAC Name: (10R,12S)-N-((2R,9S,11R,12R,14aS,15S,20S,25aS)-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,12,15-tetrahydroxy-6-((R)-1-hydroxyethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl)-10,12-dimethyltetradecanamide
InChIKey: DQXPFAADCTZLNL-RCCJUTPASA-N
SMILES: O=C([C@](NC(C(NC([C@@](C[C@@H](O)C1)([H])N1C2=O)=O)[C@H](O)[C@H](C3=CC=C(O)C=C3)O)=O)([H])[C@H](O)CC(N)=O)N4[C@@](C(N[C@@H]([C@@H](C[C@@H](C(NC2[C@H](O)C)=O)NC(CCCCCCCC[C@@H](C)C[C@@H](C)CC)=O)O)O)=O)([H])[C@@H](O)CC4
Biological Activity: Pneumocandin B0 (L-688786) is the precursor of the synthetic antifungal agent Cancidas (Caspofungin acetate) (HY-17006). Pneumocandin B0 can be isolated from fungus Glarea lozoyensis[1][2][3].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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Pneumocandin B0 | 95.06% | Pneumocandin B0 (L-688786) is the precursor of the synthetic antifungal agent Cancidas (Caspofungin acetate) (HY-17006). Pneumocandin B0 can be isolated from fungus Glarea lozoyensis. | ||||||||||||||||||||
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Similarity Score 0.93
HY-N14990Pneumocandin C0 -
Similarity Score 0.90
HY-125459L 705589 -
Similarity Score 0.90
HY-129716L-693989 -
Similarity Score 0.88
HY-N14468Pneumocandin B2 -
Similarity Score 0.85
HY-N14464Pneumocandin A1 -
Similarity Score 0.84
HY-17006ACaspofungin -
Similarity Score 0.84
HY-N14465Pneumocandin A2 -
Similarity Score 0.82
HY-17006Caspofungin diacetate -
Similarity Score 0.82
HY-W747508Aculeacin A -
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References
- [1]. Welch CJ, et al. Preparation and evaluation of novel stationary phases for improved chromatographic purification of pneumocandin B0. J Chromatogr A. 2006 Jan 6;1101(1-2):204-13. [Content Brief]
- [2]. Leonard WR Jr, et al. Synthesis of the antifungal beta-1,3-glucan synthase inhibitor CANCIDAS (caspofungin acetate) from pneumocandin B0. J Org Chem. 2007 Mar 30;72(7):2335-43. [Content Brief]
- [3]. Song P, et al. Metabolomics profiling reveals the mechanism of increased pneumocandin B0 production by comparing mutant and parent strains. J Ind Microbiol Biotechnol. 2018 Sep;45(9):767-780. [Content Brief]
