Preparation and evaluation of novel stationary phases for improved chromatographic purification of pneumocandin B0

  • J Chromatogr A. 2006 Jan 6;1101(1-2):204-13. doi: 10.1016/j.chroma.2005.10.009.
Christopher J Welch  1 ,  Jimmy O DaSilva ,  Joseph Nti-Gyabaah ,  Firoz Antia ,  Kent Goklen ,  Russell Boyd
Affiliations
  • 1. Merck Research Laboratories, Merck & Co. Inc., Rahway, NJ 07065, USA.
PMID: 16257000 DOI: 10.1016/j.chroma.2005.10.009
Abstract

Preparation and evaluation of a number of stationary phases for improved chromatographic purification of pneumocandin B0, a key intermediate in the synthesis of the Antifungal agent, Cancidas, has led to the identification of several Materials with potential for improved performance.

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