1429651-50-2
1429651-50-2
Chemical Structure
HPOB
- CAS No.: 1429651-50-2
- Formula:C17H18N2O4
- Molecular Weight:314.34
IUPAC Name: N-hydroxy-4-(2-((2-hydroxyethyl)(phenyl)amino)-2-oxoethyl)benzamide
InChIKey: RFAZNTABYJYOAR-UHFFFAOYSA-N
SMILES: O=C(N(CCO)C1=CC=CC=C1)CC2=CC=C(C(NO)=O)C=C2
Biological Activity: HPOB is a highly potent and selective inhibitor of HDAC6 with an IC50 of 56 nM. HPOB displays >30 fold less potent against other HDACs. HPOB enhances the effectiveness of DNA-damaging anticancer agents in transformed cells but not normal cells. HPOB does not block the ubiquitin-binding activity of HDAC6[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
HPOB | 99.54% | HPOB is a highly potent and selective inhibitor of HDAC6 with an IC50 of 56 nM. HPOB displays >30 fold less potent against other HDACs. HPOB enhances the effectiveness of DNA-damaging anticancer agents in transformed cells but not normal cells. HPOB does not block the ubiquitin-binding activity of HDAC6. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
Keywords
