1432051-63-2
1432051-63-2
Chemical Structure
TRPV3 antagonist 74a
- CAS No.: 1432051-63-2
- Formula:C17H17F3N2O2
- Molecular Weight:338.32
IUPAC Name: (1R,3s)-3-((S)-hydroxy(pyridin-2-yl)methyl)-1-methyl-3-(4-(trifluoromethyl)pyridin-2-yl)cyclobutan-1-ol
InChIKey: MTJXDHFAWXGXIN-OAGGEKHMSA-N
SMILES: O[C@H](C1=CC=CC=N1)[C@@]2(C3=CC(C(F)(F)F)=CC=N3)C[C@@](O)(C2)C
Biological Activity: TRPV3 antagonist 74a is a potent and selective TRPV3 antagonist. TRPV3 antagonist 74a displays no significant activity against a panel of other ion channels. TRPV3 antagonist 74a can be used for the research of neuropathic pain[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TRPV3 antagonist 74a | 99.36% | TRPV3 antagonist 74a is a potent and selective TRPV3 antagonist. TRPV3 antagonist 74a displays no significant activity against a panel of other ion channels. TRPV3 antagonist 74a can be used for the research of neuropathic pain. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.55
HY-142708α-Pyridoin -
Similarity Score 0.51
HY-W32424311β-HSD1-IN-9 -
Similarity Score 0.49
HY-12203PFK-158 -
Similarity Score 0.49
HY-123273(Rac)-Metyrapol -
Similarity Score 0.49
HY-1345616-Amino-8-trifluoromethylphenanthridine -
Similarity Score 0.49
HY-W628136MAO-B-IN-47 -
Similarity Score 0.48
HY-19679Quinacainol -
Similarity Score 0.48
![(R)-2-(9-(Pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl)acetonitrile Chemical Structure](//file.medchemexpress.com/product_pic/hy-w033729.gif)
HY-W033729(R)-2-(9-(Pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl)acetonitrile -
Similarity Score 0.48
HY-145997MRGPRX4 modulator-1 -
Explore the MedChemAI to find more analogs
![(R)-2-(9-(Pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl)acetonitrile Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w033729.gif)
References
- [1]. Gomtsyan A, et al. Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists. J Med Chem. 2016;59(10):4926-4947. [Content Brief]
- [2]. Zhao J, et al. PAR2 Mediates Itch via TRPV3 Signaling in Keratinocytes. J Invest Dermatol. 2020;140(8):1524-1532. [Content Brief]
