1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. TRPV3 antagonist 74a

TRPV3 antagonist 74a 

Cat. No.: HY-131868
Handling Instructions

TRPV3 antagonist 74a is a potent and selective TRPV3 antagonist. TRPV3 antagonist 74a displays no significant activity against a panel of other ion channels. TRPV3 antagonist 74a can be used for the research of neuropathic pain.

For research use only. We do not sell to patients.

TRPV3 antagonist 74a Chemical Structure

TRPV3 antagonist 74a Chemical Structure

CAS No. : 1432051-63-2

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Description

TRPV3 antagonist 74a is a potent and selective TRPV3 antagonist. TRPV3 antagonist 74a displays no significant activity against a panel of other ion channels. TRPV3 antagonist 74a can be used for the research of neuropathic pain[1][2].

IC50 & Target[1][2]

TRPV3

 

In Vitro

TRPV3 antagonist 74a (100 μΜ; 2300 seconds; keratinocytes) largely attenuates SLIGRL or SLIGKV-induced Ca2+ responses[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TRPV3 antagonist 74a (150 μg; intradermal injection; 30 minutes) decreases the number of scratches significantly[2].
. TRPV3 antagonist 74a (10~100 mg/kg; p.o.) dose-dependently attenuates mechanical allodynia induced by von Frey hair stimulation to the ipsilateral (injured) hind paw. TRPV3 antagonist 74a exhibits anti-nociceptive activity in the reserpine model of central pain by increasing muscle pressure threshold[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: WT mice
Dosage: 150 μg
Administration: Intradermal injection; 30 minutes
Result: The number of scratches decreased significantly.
Molecular Weight

338.32

Formula

C₁₇H₁₇F₃N₂O₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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TRPV3 antagonist 74a
Cat. No.:
HY-131868
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