1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. TRP Channel
  3. TRPV3 antagonist 74a

TRPV3 antagonist 74a is a potent and selective TRPV3 antagonist. TRPV3 antagonist 74a displays no significant activity against a panel of other ion channels. TRPV3 antagonist 74a can be used for the research of neuropathic pain.

For research use only. We do not sell to patients.

TRPV3 antagonist 74a Chemical Structure

TRPV3 antagonist 74a Chemical Structure

CAS No. : 1432051-63-2

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Description

TRPV3 antagonist 74a is a potent and selective TRPV3 antagonist. TRPV3 antagonist 74a displays no significant activity against a panel of other ion channels. TRPV3 antagonist 74a can be used for the research of neuropathic pain[1][2].

IC50 & Target[1][2]

TRPV3

 

In Vitro

TRPV3 antagonist 74a (100 μΜ; 2300 seconds; keratinocytes) largely attenuates SLIGRL or SLIGKV-induced Ca2+ responses[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TRPV3 antagonist 74a (150 μg; intradermal injection; 30 minutes) decreases the number of scratches significantly[2].
. TRPV3 antagonist 74a (10~100 mg/kg; p.o.) dose-dependently attenuates mechanical allodynia induced by von Frey hair stimulation to the ipsilateral (injured) hind paw. TRPV3 antagonist 74a exhibits anti-nociceptive activity in the reserpine model of central pain by increasing muscle pressure threshold[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: WT mice
Dosage: 150 μg
Administration: Intradermal injection; 30 minutes
Result: The number of scratches decreased significantly.
Molecular Weight

338.32

Formula

C17H17F3N2O2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H](C1=CC=CC=N1)[C@@]2(C3=CC(C(F)(F)F)=CC=N3)C[C@@](O)(C2)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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TRPV3 antagonist 74a Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
TRPV3 antagonist 74a
Cat. No.:
HY-131868
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