(Rac)-Metyrapol
Metyrapol is a steroid 11β-hydroxylase inhibitor. Metyrapol blocks the conversion of deoxycorticosterone to corticosterone in rat adrenal homogenates. Metyrapol can be used in the study of metabolic diseases.
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- CAS 番号: 17159-42-1
- 分子式: C14H16N2O
- 分子量:228.29
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Racemic metyrapol (0.4 mM; 10 min preincubation, 5 min incubation), (-)-metyrapol, and (+)-metyrapol exhibit similar inhibitory activity on steroid 11β-hydroxylase in rat adrenal homogenates, with racemic metyrapol showing 40.8% inhibition at 0.4 mM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (male, 200-250 g)[1]
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Dosage:0.1 mmol/kg; 0.25 mmol/kg; 0.5 mmol/kg
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Administration:i.v.; single dose
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Result:Recorded AUC of (-)-MOH as 0.50±0.03 mM·h, CL as 0.10±0.01 l/h·kg, and Vss as 0.63±0.15 l/kg after 0.1 mmol/kg dose.
Recorded AUC of (+)-MOH as 0.42±0.03 mM·h, CL as 0.11±0.01 l/h·kg, and Vss as 0.74±0.15 l/kg after 0.1 mmol/kg dose.
Recorded AUC of (-)-MOH as 1.41±0.33 mM·h, CL as 0.09±0.01 l/h·kg, and Vss as 0.64±0.10 l/kg after 0.25 mmol/kg dose.
Recorded AUC of (+)-MOH as 1.11±0.04 mM·h, CL as 0.11±0.01 l/h·kg, and Vss as 0.62±0.10 l/kg after 0.25 mmol/kg dose.
Recorded AUC of (-)-MOH as 2.78±0.66 mM·h, CL as 0.09±0.02 l/h·kg, and Vss as 0.53±0.06 l/kg after 0.5 mmol/kg dose.
Recorded AUC of (+)-MOH as 2.75±0.40 mM·h, CL as 0.09±0.01 l/h·kg, and Vss as 0.55±0.05 l/kg after 0.5 mmol/kg dose.
Detected insignificant formation of metyrapone from metyrapol in rat plasma.
化学情報
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CAS 番号 17159-42-1
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分子量 228.29
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分子式 C14H16N2O
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SMILES
CC(C)(C(O)C1=CC=CN=C1)C2=CC=CN=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
(Rac)-Metyrapol 関連分類
HY-123273 関連分類
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