1435-55-8
1435-55-8
Chemical Structure
Hydroquinidine
Synonym(s): Dihydroquinidine; (+)-Hydroquinidine; Hydroconquinine
- CAS No.: 1435-55-8
- Formula:C20H26N2O2
- Molecular Weight:326.44
IUPAC Name: (S)-((1S,2R,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methanol
InChIKey: LJOQGZACKSYWCH-LHHVKLHASA-N
SMILES: O[C@@H](C1=CC=NC2=C1C=C(OC)C=C2)[C@]3([H])[N@](C[C@@H]4CC)CC[C@H]4C3
Biological Activity: Hydroquinidine (Dihydroquinidine) is a potent ion channel blocker, which exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells. Hydroquinidine prolongs the QT interval and has antiarrhythmic efficacy[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Hydroquinidine | 99.97% | Hydroquinidine (Dihydroquinidine) is a potent ion channel blocker, which exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells. Hydroquinidine prolongs the QT interval and has antiarrhythmic efficacy. | ||||||||||||||||||||
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Hydroquinidine (Standard) | ≥98% | Hydroquinidine (Standard) is the analytical standard of Hydroquinidine. This product is intended for research and analytical applications. Hydroquinidine (Dihydroquinidine) is a derivative of Quinidine (an antiarrhythmic agent). Hydroquinidine prolongs the QT interval and has antiarrhythmic efficacy. | ||||||||||||||||||||
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References
- [1]. Mazzanti A, et, al. Hydroquinidine Prevents Life-Threatening Arrhythmic Events in Patients With Short QT Syndrome. J Am Coll Cardiol. 2017 Dec 19;70(24):3010-3015. [Content Brief]
- [2]. Hermida JS, et, al. Hydroquinidine therapy in Brugada syndrome. J Am Coll Cardiol. 2004 May 19;43(10):1853-60. [Content Brief]
- [3]. Chimienti M, et, al. Comparison of the effectiveness of dihydroquinidine and quinidine on ventricular ectopy after acute and chronic administration. Cardiovasc Drugs Ther. 1988 Dec;2(5):679-86. [Content Brief]
- [4]. Mazzanti A, et al. Hydroquinidine Prevents Life-Threatening Arrhythmic Events in Patients With Short QT Syndrome. J Am Coll Cardiol. 2017 Dec 19;70(24):3010-3015. [Content Brief]
- [5]. Yavuz M, et al. A potent ion channel blocker, hydroquinidine, exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells. Mol Biol Rep. 2023 Mar;50(3):2611-2621. [Content Brief]
