144608-09-3
144608-09-3
Chemical Structure
Schizotenuin A
- CAS No.: 144608-09-3
- Formula:C36H28O16
- Molecular Weight:716.60
InChIKey: KROVXXIIXUFKOO-NGJWAYPNSA-N
SMILES: OC(C=C1C[C@H](C(O)=O)OC(C(C2=CC(/C=C/C(O[C@@H](C(O)=O)CC3=CC(O)=C(C=C3)O)=O)=C4)=C(C5=CC(O)=C(C=C5)O)OC2=C4O)=O)=C(C=C1)O
Biological Activity: Schizotenuin A is a Aβ and hIAPP fibrillation inhibitor with human-derived IC50 values of 2.93 µM and 0.58 µM, respectively, and exhibits antioxidant activity. Schizotenuin A scavenges DPPH free radicals and inhibits lipid peroxidation in rat liver microsomes. Schizotenuin A can be used in research related to Alzheimer's disease and type 2 diabetes[1][2].
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Schizotenuin A | Schizotenuin A is a Aβ and hIAPP fibrillation inhibitor with human-derived IC50 values of 2.93 µM and 0.58 µM, respectively, and exhibits antioxidant activity. Schizotenuin A scavenges DPPH free radicals and inhibits lipid peroxidation in rat liver microsomes. Schizotenuin A can be used in research related to Alzheimer's disease and type 2 diabetes. | |||||||||||||||||||||
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References
- [1]. Sun J, et al. Inhibitory activities of phenylpropanoids from Lycopus lucidus on amyloid aggregation related to Alzheimer's disease and type 2 diabetes. Journal of natural medicines. 2020 Jun;74(3):579-583. [Content Brief]
- [2]. Chand K, et al. A review on antioxidant potential of bioactive heterocycle benzofuran: Natural and synthetic derivatives. Pharmacological reports : PR. 2017 Apr;69(2):281-295. [Content Brief]
