1453099-83-6
1453099-83-6
Chemical Structure
TAS-119
Synonym(s): VIC-1911
- CAS No.: 1453099-83-6
- Formula:C23H22Cl2FN5O3
- Molecular Weight:506.36
IUPAC Name: 1-(2,3-dichlorobenzoyl)-4-((5-fluoro-6-((5-methyl-1H-pyrazol-3-yl)amino)pyridin-2-yl)methyl)piperidine-4-carboxylic acid
InChIKey: PLAVWQHGBMTMFR-UHFFFAOYSA-N
SMILES: O=C(C1(CC2=NC(NC3=NNC(C)=C3)=C(F)C=C2)CCN(C(C4=CC=CC(Cl)=C4Cl)=O)CC1)O
Biological Activity: TAS-119 is a potent, selective and orally active Aurora A inhibitor with an IC50 of 1.0 nM. TAS-119 shows high selectivity for Aurora A over other protein kinases, including Aurora B (IC50 of 95 nM). TAS-119 has potent antitumor activites[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TAS-119 | 98.01% | TAS-119 is a potent, selective and orally active Aurora A inhibitor with an IC50 of 1.0 nM. TAS-119 shows high selectivity for Aurora A over other protein kinases, including Aurora B (IC50 of 95 nM). TAS-119 has potent antitumor activites. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.66
HY-179643Aurora-A ligand 2 -
Similarity Score 0.62
HY-114258LY3295668 -
Similarity Score 0.60
HY-114258ALY3295668 erbumine -
Similarity Score 0.58
HY-143713Aurora A inhibitor 1 -
Similarity Score 0.58
HY-157396JAB-2485 -
Similarity Score 0.51
HY-1624696K465 -
Similarity Score 0.50
HY-13252MK-5108 -
Similarity Score 0.49
HY-128901F 13714 fumarate -
Similarity Score 0.49
HY-U00304Aurora B inhibitor 1 -
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