1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. F13714 fumarate

F13714 fumarate 

Cat. No.: HY-128901 Purity: 98.65%
Handling Instructions

F13714 fumarate, a selective 5-HT1A receptor biased agonist, shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress.

For research use only. We do not sell to patients.

F13714 fumarate Chemical Structure

F13714 fumarate Chemical Structure

CAS No. : 208109-39-1

Size Price Stock Quantity
5 mg USD 280 In-stock
Estimated Time of Arrival: December 31
10 mg USD 460 In-stock
Estimated Time of Arrival: December 31
25 mg USD 850 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

F13714 fumarate, a selective 5-HT1A receptor biased agonist, shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress[1].

IC50 & Target[1]

5-HT1A Receptor

 

In Vitro

F13714 targets 5-HT1A autoreceptors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In UCMS mice, a single administration of F13714 (4–16 mg/kg) is sufficient to robustly normalize depressive-like behavior in the forced swim test (FST). F13714 rescues cortical and hippocampal deficits in p-ERK1/2 levels but does not influence the p-CREB levels[1].
F13714 decreases the immobility in mice at the doses 2 and 4 mg/kg by 30.3% and 19.5%[1].
F13714 (0.5-2 mg/kg) given alone significantly and dose-dependently decreases rectal body temperature in mice during a 2-h measurement[1].
F13714 (2.5 mg/kg) possess antidepressant-and anxiolytic-like properties in naïve rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

538.97

Formula

C₂₅H₂₉ClF₂N₄O₅

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (463.85 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8554 mL 9.2770 mL 18.5539 mL
5 mM 0.3711 mL 1.8554 mL 3.7108 mL
10 mM 0.1855 mL 0.9277 mL 1.8554 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.64 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.64 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
F13714 fumarate
Cat. No.:
HY-128901
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