145508-78-7
Chemical Structure
Icopezil
Synonym(s): CP-118954
- CAS No.: 145508-78-7
- Formula:C23H25N3O2
- Molecular Weight:375.46
IUPAC Name: 3-(2-(1-benzylpiperidin-4-yl)ethyl)-5,7-dihydro-6H-isoxazolo[4,5-f]indol-6-one
InChIKey: MTCMTKNMZCPKLX-UHFFFAOYSA-N
SMILES: O=C1NC2=CC3=C(C=C2C1)C(CCC4CCN(CC4)CC5=CC=CC=C5)=NO3
Biological Activity: Icopezil (CP-118954) is an orally active, selective AchE inhibitor with an IC50 of 0.33 nM. Icopezil increases acetylcholine levels in the brain and striatum of mammals, induces centrally mediated tremors and peripherally mediated salivation, and improves working memory performance in aged dogs. Icopezil serves as a parent compound for radioiodine-labeled acetylcholinesterase imaging agents. Icopezil is applicable to research related to Alzheimer's disease[1][2][3][4].
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Icopezil | Icopezil (CP-118954) is an orally active, selective AchE inhibitor with an IC50 of 0.33 nM. Icopezil increases acetylcholine levels in the brain and striatum of mammals, induces centrally mediated tremors and peripherally mediated salivation, and improves working memory performance in aged dogs. Icopezil serves as a parent compound for radioiodine-labeled acetylcholinesterase imaging agents. Icopezil is applicable to research related to Alzheimer's disease. | |||||||||||||||||||||
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- [1]. Liston DR, et al. Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease. European journal of pharmacology. 2004 Feb 13;486(1):9-17. [Content Brief]
- [2]. Studzinski CM, et al. The canine model of human cognitive aging and dementia: pharmacological validity of the model for assessment of human cognitive-enhancing drugs. Progress in neuro-psychopharmacology & biological psychiatry. 2005 Mar;29(3):489-98. [Content Brief]
- [3]. Muñoz-Torrero D, et al. Dimeric and hybrid anti-Alzheimer drug candidates. Current medicinal chemistry. 2006;13(4):399-422. [Content Brief]
- [4]. Lee I, et al. Synthesis and evaluation of radioiodine-labelled CP-118,954 for the in-vivo imaging of acetylcholinesterase. Nucl Med Commun. 2007 Jul;28(7):561-6. [Content Brief]
Keywords
