145902-81-4
Chemical Structure
(-)-BO 2367
- CAS No.: 145902-81-4
- Formula:C21H22ClF2N3O3
- Molecular Weight:437.87
IUPAC Name: 7-((3aR,4R,7aS)-4-amino-1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-yl)-1-cyclopropyl-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
InChIKey: HLOXEUWOJLFTQE-LGGAFPCMSA-N
SMILES: FC1=C2N(C3CC3)C=C(C(C2=CC(F)=C1N4C[C@@]5([H])[C@@](CC=C[C@H]5N)([H])C4)=O)C(O)=O.Cl
Biological Activity: (-)-BO 2367, an antimicrobial quinolone, is a strong mammalian and bacterial topoisomerase II inhibitor. (-)-BO 2367 shows IC50 values with 3.8 μM, 0.5 μM, and 1 μM against the DNA relaxation activity of L1210 topoisomerase II and the supercoiling activities of Escherichia coli gyrase and Micrococcus luteus gyrase, respectively. (-)-BO 2367 is a potent antitumor agent[1].
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(-)-BO 2367 | (-)-BO 2367, an antimicrobial quinolone, is a strong mammalian and bacterial topoisomerase II inhibitor. (-)-BO 2367 shows IC50 values with 3.8 μM, 0.5 μM, and 1 μM against the DNA relaxation activity of L1210 topoisomerase II and the supercoiling activities of Escherichia coli gyrase and Micrococcus luteus gyrase, respectively. (-)-BO 2367 is a potent antitumor agent. | |||||||||||||||||||||
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Keywords
