146385-37-7
Chemical Structure
Biotin-NAD+
- CAS No.: 146385-37-7
- Formula:C39H57N11O17P2S
- Molecular Weight:1045.95
IUPAC Name: 3-carbamoyl-1-((2R,3R,4S,5R)-5-((((((((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-((2-oxo-2-((6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexyl)amino)ethyl)amino)-9H-purin-9-yl)tetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)oxidophosphoryl)oxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)pyridin-1-ium
InChIKey: MIIADCCJYSONEI-RNWYXDGLSA-N
SMILES: O=C(NCCCCCCNC(CCCC[C@H]1[C@](NC2=O)([H])[C@](N2)([H])CS1)=O)CNC3=C4C(N(C=N4)[C@@H]5O[C@H](COP(O)(OP(OC[C@@H]6[C@@H](O)[C@@H](O)[C@H]([N+]7=CC=CC(C(N)=O)=C7)O6)([O-])=O)=O)[C@@H](O)[C@H]5O)=NC=N3
Biological Activity: Biotin-NAD+ is a PARylation donor and also a substrate of poly (ADP-ribose) polymerase-1 (PARP1). Under the mediation of PARP1, Biotin-NAD+ undergoes poly (ADP-ribosyl) ation to generate biotinylated poly (ADP-ribose) polymers. Biotin-NAD+ can be used for pull-down assays of PARylated proteins in renal epithelial cells. Biotin-NAD+ is applicable to cancer-related research[1].
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Biotin-NAD+ | Biotin-NAD+ is a PARylation donor and also a substrate of poly (ADP-ribose) polymerase-1 (PARP1). Under the mediation of PARP1, Biotin-NAD+ undergoes poly (ADP-ribosyl) ation to generate biotinylated poly (ADP-ribose) polymers. Biotin-NAD+ can be used for pull-down assays of PARylated proteins in renal epithelial cells. Biotin-NAD+ is applicable to cancer-related research. | |||||||||||||||||||||
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