1487375-69-8
Chemical Structure
Cereulide-13C6
- CAS No.: 1487375-69-8
- Formula:C5113C6H96N6O18
- Molecular Weight:1159.36
IUPAC Name: 3-((1S,2S)-2-((bis(methyl-d3)amino)methyl)-1-hydroxycyclohexyl)phenol
InChIKey: JWWAHGUHYLWQCQ-NUOMGVRCSA-N
SMILES: CC(C)C[C@H]1O[13C]([C@@H](NC([C@@H](OC([C@H](NC([C@H](O[13C]([C@@H](NC([C@@H](OC([C@H](NC([C@H](O[13C]([C@@H](NC([C@@H](OC([C@H](NC1=O)[13CH3])=O)C(C)C)=O)C(C)C)=O)CC(C)C)=O)[13CH3])=O)C(C)C)=O)C(C)C)=O)CC(C)C)=O)[13CH3])=O)C(C)C)=O)C(C)C)=O
Biological Activity: Cereulide-13C6 is a deuterated form of Cereulide. Cereulide is an orally active, blood-brain barrier-permeable emetic toxin. Cereulide acts as a potassium ionophore that inserts into membranes, forms complexes with K+, and transports K+ from the cytoplasm into the mitochondrial matrix. Cereulide disrupts the electrochemical gradient of the inner mitochondrial membrane, leading to mitochondrial swelling and dysfunction, uncoupling of oxidative phosphorylation, inhibition of ATP synthesis, ROS accumulation, and ultimately triggering apoptosis and autophagy. Cereulide exhibits multi-organ toxicity and can be used for research on emetic food poisoning.
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Cereulide-13C6 | 97% | Cereulide-13C6 is a deuterated form of Cereulide. Cereulide is an orally active, blood-brain barrier-permeable emetic toxin. Cereulide acts as a potassium ionophore that inserts into membranes, forms complexes with K+, and transports K+ from the cytoplasm into the mitochondrial matrix. Cereulide disrupts the electrochemical gradient of the inner mitochondrial membrane, leading to mitochondrial swelling and dysfunction, uncoupling of oxidative phosphorylation, inhibition of ATP synthesis, ROS accumulation, and ultimately triggering apoptosis and autophagy. Cereulide exhibits multi-organ toxicity and can be used for research on emetic food poisoning. | ||||||||||||||||||||
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Cereulide | 95.05% | Cereulide is an orally active, blood-brain barrier-permeable emetic toxin. Cereulide acts as a potassium ionophore that inserts into membranes, forms complexes with K+, and transports K+ from the cytoplasm into the mitochondrial matrix. Cereulide disrupts the electrochemical gradient of the inner mitochondrial membrane, leading to mitochondrial swelling and dysfunction, uncoupling of oxidative phosphorylation, inhibition of ATP synthesis, ROS accumulation, and ultimately triggering apoptosis and autophagy. Cereulide exhibits multi-organ toxicity and can be used for research on emetic food poisoning. | ||||||||||||||||||||
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Keywords
