15548-51-3
15548-51-3
Chemical Structure
5'-TMPS
Synonym(s): Thymidine-5'-O-monophosphorothioate
- CAS. Nr.: 15548-51-3
- Formula:C10H15N2O7PS
- Molecular Weight:338.27
IUPAC Name: O-(((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl) O,S-dihydrogen phosphorothioate
InChIKey: OJRKJKYGUAALCJ-XLPZGREQSA-N
SMILES: O=C(C(C)=CN1[C@H]2C[C@H](O)[C@@H](COP(O)(S)=O)O2)NC1=O
Biological Activity: 5'-TMPS (Thymidine-5'-O-monophosphorothioate) is a selective partial agonist of P2Y6R and an antagonist of P2Y14R. Additionally, 5'-TMPS acts as a positive regulator of angiogenesis, exhibiting pro-angiogenic effects[1][2]
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5'-TMPS | 5'-TMPS (Thymidine-5'-O-monophosphorothioate) is a selective partial agonist of P2Y6R and an antagonist of P2Y14R. Additionally, 5'-TMPS acts as a positive regulator of angiogenesis, exhibiting pro-angiogenic effects | |||||||||||||||||||||
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References
- [1]. Rafehi M, et al. Tools and drugs for uracil nucleotide-activated P2Y receptors[J]. Pharmacology & Therapeutics, 2018, 190: 24-80. [Content Brief]
- [2]. Węgłowska E, et al. Extracellular nucleotides affect the proangiogenic behavior of fibroblasts, keratinocytes, and endothelial cells[J]. International Journal of Molecular Sciences, 2021, 23(1): 238. [Content Brief]
