160212-35-1
Chemical Structure
Nelipepimut-S
Synonym(s): E75; E75 peptide
- CAS No.: 160212-35-1
- Formula:C50H78N10O11
- Molecular Weight:995.21
IUPAC Name: L-lysyl-L-isoleucyl-L-phenylalanylglycyl-L-seryl-L-leucyl-L-alanyl-L-phenylalanyl-L-leucine
InChIKey: AHOKKYCUWBLDST-QYULHYBRSA-N
SMILES: CC(C)C[C@@H](C(O)=O)NC([C@@H](NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](CO)NC(CNC([C@@H](NC([C@H]([C@@H](C)CC)NC([C@@H](N)CCCCN)=O)=O)CC1=CC=CC=C1)=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O
Biological Activity: Nelipepimut-S (E75) is a peptide vaccine targeting HER2. When used in combination with granulocyte-macrophage colony-stimulating factor, Nelipepimut-S stimulates immune activity and induces anti-HER2 immune responses. Nelipepimut-S can be used in research related to breast cancer, triple-negative breast cancer and ductal carcinoma in situ[1][2].
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Nelipepimut-S | Nelipepimut-S (E75) is a peptide vaccine targeting HER2. When used in combination with granulocyte-macrophage colony-stimulating factor, Nelipepimut-S stimulates immune activity and induces anti-HER2 immune responses. Nelipepimut-S can be used in research related to breast cancer, triple-negative breast cancer and ductal carcinoma in situ. | |||||||||||||||||||||
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References
- [1]. Dillon PM, et al. Evaluating Nelipepimut-S in the Treatment of Breast Cancer: A Short Report on the Emerging Data. Breast cancer (Dove Medical Press). 2020;12:69-75. [Content Brief]
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[2]. Clifton GT, et al. The development and use of the E75 (HER2 369-377) peptide vaccine. Future Oncol. 2016 Jun;12(11):1321-9.
[Content Brief]
