160472-93-5
Chemical Structure
Acinetobactin
- CAS No.: 160472-93-5
- Formula:C16H18N4O5
- Molecular Weight:346.34
IUPAC Name: N-((4S,5S)-2-(2-(1H-imidazol-5-yl)ethyl)-5-methyl-3-oxoisoxazolidin-4-yl)-2,3-dihydroxybenzamide
InChIKey: YQXURFXJBIFMOA-ZANVPECISA-N
SMILES: O=C(C1=C(C(O)=CC=C1)O)N[C@@H]2C(N(O[C@H]2C)CCC3=CN=CN3)=O
Biological Activity: Acinetobactin is a bifunctional siderophore secreted by Acinetobacter baumannii that competitively binds ferric iron ions. Acinetobactin supplies A. baumannii by sequestering host-sequestered Fe3+, while competitively depriving skin and respiratory commensal bacteria of iron resources, thereby exerting growth-inhibitory effects on Staphylococcus epidermidis, Staphylococcus hominis, Staphylococcus haemolyticus, and Corynebacterium striatum. The synthesis and transport of Acinetobactin enhance the intracellular epithelial colonization ability of A. baumannii, induce apoptosis of host epithelial cells, and simultaneously improve the survival and invasion capabilities of the bacterium in Galleria mellonella and mouse sepsis models. Acinetobactin can be used in A. baumannii-related research[1][2][3].
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Acinetobactin | Acinetobactin is a bifunctional siderophore secreted by Acinetobacter baumannii that competitively binds ferric iron ions. Acinetobactin supplies A. baumannii by sequestering host-sequestered Fe3+, while competitively depriving skin and respiratory commensal bacteria of iron resources, thereby exerting growth-inhibitory effects on Staphylococcus epidermidis, Staphylococcus hominis, Staphylococcus haemolyticus, and Corynebacterium striatum. The synthesis and transport of Acinetobactin enhance the intracellular epithelial colonization ability of A. baumannii, induce apoptosis of host epithelial cells, and simultaneously improve the survival and invasion capabilities of the bacterium in Galleria mellonella and mouse sepsis models. Acinetobactin can be used in A. baumannii-related research. | |||||||||||||||||||||
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- [1]. Knauf GA, et al. Acinetobactin-Mediated Inhibition of Commensal Bacteria by Acinetobacter baumannii. mSphere. 2022 Feb 23;7(1):e0001622. [Content Brief]
- [2]. Gaddy JA, et al. Role of acinetobactin-mediated iron acquisition functions in the interaction of Acinetobacter baumannii strain ATCC 19606T with human lung epithelial cells, Galleria mellonella caterpillars, and mice. Infection and immunity. 2012 Mar;80(3):1015-24. [Content Brief]
- [3]. Yamamoto S, et al. Isolation and structure elucidation of acinetobactin, a novel siderophore from Acinetobacter baumannii. Archives of microbiology. 1994;162(4):249-54. [Content Brief]
Keywords
