1620107-33-6
1620107-33-6
Chemical Structure
LU-005i
- CAS No.: 1620107-33-6
- Formula:C31H46N4O7
- Molecular Weight:586.72
IUPAC Name: (S)-N-((S)-3-cyclohexyl-1-((R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-(4-methoxyphenyl)-2-((S)-2-(2-morpholinoacetamido)propanamido)propanamide
InChIKey: UHNYITHLNFUAIN-VTNASVEKSA-N
SMILES: COC(C=C1)=CC=C1C[C@H](NC([C@H](C)NC(CN2CCOCC2)=O)=O)C(N[C@@H](CC3CCCCC3)C([C@]4(CO4)C)=O)=O
Biological Activity: LU-005i is a potent inhibitor of β5i subunit of immunoproteasomes (IC50 = 6.6 nM), selective over β5c subunit (IC50 = 287 nM)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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LU-005i | 98.24% | LU-005i is a potent inhibitor of β5i subunit of immunoproteasomes (IC50 = 6.6 nM), selective over β5c subunit (IC50 = 287 nM). | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.93
HY-157035Proteasome β2c/i-IN-1 -
Similarity Score 0.88
HY-157034LU-002i -
Similarity Score 0.77
HY-13207ONX-0914 -
Similarity Score 0.72
HY-114419Zetomipzomib -
Similarity Score 0.67
HY-114419AZetomipzomib maleate -
Similarity Score 0.64
HY-187220β5i-IN-2 -
Similarity Score 0.63
HY-10455Carfilzomib -
Similarity Score 0.56
HY-I0775(S)-methyl 2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenylpropanoate -
Similarity Score 0.56
HY-Z0028(S)-N-((S)-1-(((2R,4S)-1,2-Dihydroxy-2,6-dimethyl-3-oxoheptan-4-yl)amino)-1-oxo-3-phenylpropan-2-yl)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide -
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