LU-005i
Based on 1 Customer Validation
LU-005i is a potent inhibitor of β5i subunit of immunoproteasomes (IC50 = 6.6 nM), selective over β5c subunit (IC50 = 287 nM).
For research use only. We do not sell to patients.
- Purity: 98.24%
- CAS No.: 1620107-33-6
- Formula: C31H46N4O7
- Molecular Weight:586.72
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
β5i subunit of immunoproteasomes (IC50 = 6.6 nM), β5c subunit of immunoproteasomes (IC50 = 287 nM)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Raji | IC50 |
>10 μM
Compound: 8, LU-005i
|
Inhibition of 20s proteasome subunit beta-1c in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry
Inhibition of 20s proteasome subunit beta-1c in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry
|
[PMID: 25006746] |
| Raji | IC50 |
0.3 μM
Compound: 8, LU-005i
|
Inhibition of proteasome subunit beta-1i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry
Inhibition of proteasome subunit beta-1i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry
|
[PMID: 25006746] |
| Raji | IC50 |
0.41 μM
Compound: 8, LU-005i
|
Inhibition of proteasome subunit beta-2i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry
Inhibition of proteasome subunit beta-2i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry
|
[PMID: 25006746] |
| Raji | IC50 |
2.5 μM
Compound: 8, LU-005i
|
Inhibition of 20s proteasome subunit beta-2c in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry
Inhibition of 20s proteasome subunit beta-2c in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry
|
[PMID: 25006746] |
| Raji | IC50 |
287 nM
Compound: 8, LU-005i
|
Inhibition of 20s proteasome subunit beta-5c in human Raji cells using BODIPY-NC005 by fluorescent densitometry
Inhibition of 20s proteasome subunit beta-5c in human Raji cells using BODIPY-NC005 by fluorescent densitometry
|
[PMID: 25006746] |
| Raji | IC50 |
6.6 nM
Compound: 8, LU-005i
|
Inhibition of proteasome subunit beta-5i in human Raji cells using BODIPY-NC005 by fluorescent densitometry
Inhibition of proteasome subunit beta-5i in human Raji cells using BODIPY-NC005 by fluorescent densitometry
|
[PMID: 25006746] |
| RPMI-8226 | IC50 |
>5 μM
Compound: 8, LU-005i
|
Inhibition of 20s proteasome subunit beta-1c in human RPMI8226 cells using BODIPY-NC001 by fluorescent densitometry
Inhibition of 20s proteasome subunit beta-1c in human RPMI8226 cells using BODIPY-NC001 by fluorescent densitometry
|
[PMID: 25006746] |
| RPMI-8226 | IC50 |
0.044 μM
Compound: 8, LU-005i
|
Inhibition of proteasome subunit beta-5i in human RPMI8226 cells using BODIPY-NC005 by fluorescent densitometry
Inhibition of proteasome subunit beta-5i in human RPMI8226 cells using BODIPY-NC005 by fluorescent densitometry
|
[PMID: 25006746] |
| RPMI-8226 | IC50 |
0.37 μM
Compound: 8, LU-005i
|
Inhibition of proteasome subunit beta-1i in human RPMI8226 cells using BODIPY-NC001 by fluorescent densitometry
Inhibition of proteasome subunit beta-1i in human RPMI8226 cells using BODIPY-NC001 by fluorescent densitometry
|
[PMID: 25006746] |
| RPMI-8226 | IC50 |
0.9 μM
Compound: 8, LU-005i
|
Inhibition of proteasome subunit beta-2i in human RPMI8226 cells using BODIPY-epoxomicin by fluorescent densitometry
Inhibition of proteasome subunit beta-2i in human RPMI8226 cells using BODIPY-epoxomicin by fluorescent densitometry
|
[PMID: 25006746] |
| RPMI-8226 | IC50 |
4.2 μM
Compound: 8, LU-005i
|
Inhibition of 20s proteasome subunit beta-5c in human RPMI8226 cells using BODIPY-NC005 by fluorescent densitometry
Inhibition of 20s proteasome subunit beta-5c in human RPMI8226 cells using BODIPY-NC005 by fluorescent densitometry
|
[PMID: 25006746] |
| RPMI-8226 | IC50 |
4.9 μM
Compound: 8, LU-005i
|
Inhibition of 20s proteasome subunit beta-2c in human RPMI8226 cells using BODIPY-epoxomicin by fluorescent densitometry
Inhibition of 20s proteasome subunit beta-2c in human RPMI8226 cells using BODIPY-epoxomicin by fluorescent densitometry
|
[PMID: 25006746] |
Chemical Information
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CAS No. 1620107-33-6
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Appearance Solid
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Molecular Weight 586.72
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Formula C31H46N4O7
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Color White to off-white
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SMILES
COC(C=C1)=CC=C1C[C@H](NC([C@H](C)NC(CN2CCOCC2)=O)=O)C(N[C@@H](CC3CCCCC3)C([C@]4(CO4)C)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (170.44 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7044 mL | 8.5220 mL | 17.0439 mL | 42.6098 mL |
| 5 mM | 0.3409 mL | 1.7044 mL | 3.4088 mL | 8.5220 mL | |
| 10 mM | 0.1704 mL | 0.8522 mL | 1.7044 mL | 4.2610 mL | |
| 15 mM | 0.1136 mL | 0.5681 mL | 1.1363 mL | 2.8407 mL | |
| 20 mM | 0.0852 mL | 0.4261 mL | 0.8522 mL | 2.1305 mL | |
| 25 mM | 0.0682 mL | 0.3409 mL | 0.6818 mL | 1.7044 mL | |
| 30 mM | 0.0568 mL | 0.2841 mL | 0.5681 mL | 1.4203 mL | |
| 40 mM | 0.0426 mL | 0.2130 mL | 0.4261 mL | 1.0652 mL | |
| 50 mM | 0.0341 mL | 0.1704 mL | 0.3409 mL | 0.8522 mL | |
| 60 mM | 0.0284 mL | 0.1420 mL | 0.2841 mL | 0.7102 mL | |
| 80 mM | 0.0213 mL | 0.1065 mL | 0.2130 mL | 0.5326 mL | |
| 100 mM | 0.0170 mL | 0.0852 mL | 0.1704 mL | 0.4261 mL |
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