162045-26-3
162045-26-3
Chemical Structure
L-372662
- CAS No.: 162045-26-3
- Formula:C33H38N4O6
- Molecular Weight:586.68
IUPAC Name: 3-((4-(3-methoxy-4-(4-(2-oxo-2H-benzo[d][1,3]oxazin-1(4H)-yl)piperidine-1-carbonyl)phenoxy)piperidin-1-yl)methyl)-2-methylpyridine 1-oxide
InChIKey: SKWSXDUHUVMPBT-UHFFFAOYSA-N
SMILES: O=C(OC1)N(C2CCN(C(C3=C(OC)C=C(OC4CCN(CC5=C(C)[N+]([O-])=CC=C5)CC4)C=C3)=O)CC2)C6=C1C=CC=C6
Biological Activity: L-372662 is a potent and orally active non-peptide oxytocin antagonist with a Ki value of 4.8. The Kd value of L-372662 for wild-type hOTR and [A318G]OTR is 5.8 nM and 73 nM. L-372662 shows selectivity to OTR:V1aR[1][2].
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L-372662 | 99.24% | L-372662 is a potent and orally active non-peptide oxytocin antagonist with a Ki value of 4.8. The Kd value of L-372662 for wild-type hOTR and [A318G]OTR is 5.8 nM and 73 nM. L-372662 shows selectivity to OTR:V1aR. | ||||||||||||||||||||
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References
- [1]. Bell, I. M., Erb, J. M., Freidinger, R. M., Gallicchio, S. N., Guare, J. P., Guidotti, M. T., … Woyden, C. J. (1998). Development of Orally Active Oxytocin Antagonists: Studies on 1-(1-{4-[1-(2-Methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2- metho
- [2]. Hawtin SR, et al. A Gly/Ala switch contributes to high affinity binding of benzoxazinone-based non-peptide oxytocin receptor antagonists. FEBS Lett. 2005;579(2):349-356. [Content Brief]
