1623481-80-0
1623481-80-0
Chemical Structure
ML381
Synonym(s): VU0488130
- CAS No.: 1623481-80-0
- Formula:C21H21N3O4
- Molecular Weight:379.41
IUPAC Name: (S)-5-((3-acetylphenoxy)methyl)-N-methyl-N-(1-(pyridin-2-yl)ethyl)isoxazole-3-carboxamide
InChIKey: JMYDHMCYZKRDPD-AWEZNQCLSA-N
SMILES: O=C(C1=NOC(COC2=CC=CC(C(C)=O)=C2)=C1)N(C)[C@H](C3=NC=CC=C3)C
Biological Activity: ML381 (VU0488130) is a highly selective, central nervous system penetrant mAChR M5 orthogonal antagonist (IC50 = 450 nM; Ki = 340 nM). ML381 is unstable in rat plasma and can be mainly used as a molecular probe for in vitro and electrophysiological studies[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ML381 | 99.87% | ML381 (VU0488130) is a highly selective, central nervous system penetrant mAChR M5 orthogonal antagonist (IC50 = 450 nM; Ki = 340 nM). ML381 is unstable in rat plasma and can be mainly used as a molecular probe for in vitro and electrophysiological studies. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.51
HY-16670Dafadine-A -
Similarity Score 0.50
HY-163763T-10418 -
Similarity Score 0.50
HY-181846nTRD22 -
Similarity Score 0.49
HY-151576PRMT5:MEP50 PPI -
Similarity Score 0.48
HY-165155CysLT1 receptor antagonist-1 -
Similarity Score 0.48
HY-116452YLT192 -
Similarity Score 0.48
HY-168784LTD4 antagonist 2 -
Similarity Score 0.47
HY-W1130195-(Naphthalen-1-ylmethoxy)isophthalicacid -
Similarity Score 0.47
HY-124655S1PL-IN- 2 -
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