LTD4 antagonist 2
LTD4 antagonist 2 (compound 6) is a leukotriene D4 (LTD4) antagonist with an IC50 of 2.8 μM against cysteinyl leukotriene 1 receptor (CysLT1R). LTD4 antagonist 2 is also a G protein-coupled bile acid receptor 1 (GPBAR1) agonist and can be utilized in research related to colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases.
For research use only. We do not sell to patients.
- CAS No.: 107813-86-5
- Formula: C17H13NO3
- Molecular Weight:279.29
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Leukotriene Receptor Isoforms
More
Biological Activity
Chemical Information
-
CAS No. 107813-86-5
-
Molecular Weight 279.29
-
Formula C17H13NO3
-
SMILES
O=C(C1=CC(OCC2=NC3=C(C=C2)C=CC=C3)=CC=C1)O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Fiorillo B, et al. Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1. J Med Chem. 2021 Nov 25;64(22):16512-16529. [Content Brief]
[2]. Musser JH, et al. N-[(arylmethoxy)phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides. Potent orally active leukotriene D4 antagonists of novel structure. J Med Chem. 1990 Jan;33(1):240-5. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LTD4 antagonist 2 Related Classifications
HY-168784 Related Classifications
Powered by Bioz