163660-53-5
Chemical Structure
(R)-MDL-101146
- CAS No.: 163660-53-5
- Formula:C29H37F5N4O6
- Molecular Weight:632.62
IUPAC Name: (S)-1-((4-(morpholine-4-carbonyl)benzoyl)-L-valyl)-N-((R)-5,5,6,6,6-pentafluoro-2-methyl-4-oxohexan-3-yl)pyrrolidine-2-carboxamide
InChIKey: XQAMVCHQGHAELT-BDTNDASRSA-N
SMILES: CC(C)[C@@H](C(N1[C@H](C(N[C@H](C(C)C)C(C(C(F)(F)F)(F)F)=O)=O)CCC1)=O)NC(C2=CC=C(C(N3CCOCC3)=O)C=C2)=O
Biological Activity: (R)-MDL-101146 is the R-isomer of MDL-101146. MDL-101146 is an orally active, competitive and reversible inhibitor against human neutrophil elastase (HNE) with a Ki value of 25 nM. MDL-101146 inhibits HNE-induced hemorrhage in hamsters. MDL-101146 is promising for research of emphysema, rheumatoid arthritis, chronic bronchitis, cystic fibrosis, adult respiratory distress syndrome and glomerulonephritis[1].
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(R)-MDL-101146 | (R)-MDL-101146 is the R-isomer of MDL-101146. MDL-101146 is an orally active, competitive and reversible inhibitor against human neutrophil elastase (HNE) with a Ki value of 25 nM. MDL-101146 inhibits HNE-induced hemorrhage in hamsters. MDL-101146 is promising for research of emphysema, rheumatoid arthritis, chronic bronchitis, cystic fibrosis, adult respiratory distress syndrome and glomerulonephritis. | |||||||||||||||||||||
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Keywords
