164658-13-3
164658-13-3
Chemical Structure
CGP60474
- CAS No.: 164658-13-3
- Formula:C18H18ClN5O
- Molecular Weight:355.82
IUPAC Name: 3-((4-(2-((3-chlorophenyl)amino)pyrimidin-4-yl)pyridin-2-yl)amino)propan-1-ol
InChIKey: IYNDTACKOAXKBJ-UHFFFAOYSA-N
SMILES: ClC1=CC(NC2=NC=CC(C3=CC=NC(NCCCO)=C3)=N2)=CC=C1
Biological Activity: CGP60474, a highly potent anti-endotoxemic agent, is a potent cyclin-dependent kinase (CDK) inhibitor (IC50 values are 26, 3, 4, 216, 10, 200 and 13 nM for CDK1/B, CDK2/E, CDK2/A, CDK4/D, CDK5/p25, CDK7/H and CDK9/T, respectively). CGP60474 is a selective and ATP-competitive PKC inhibitor[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CGP60474 | 98.90% | CGP60474, a highly potent anti-endotoxemic agent, is a potent cyclin-dependent kinase (CDK) inhibitor (IC50 values are 26, 3, 4, 216, 10, 200 and 13 nM for CDK1/B, CDK2/E, CDK2/A, CDK4/D, CDK5/p25, CDK7/H and CDK9/T, respectively). CGP60474 is a selective and ATP-competitive PKC inhibitor. | ||||||||||||||||||||
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CGP60474 (Standard) | ≥98% | CGP60474 (Standard) is the analytical standard of CGP60474 (HY-11009). This product is intended for research and analytical applications. CGP60474, a highly potent anti-endotoxemic agent, is a potent cyclin-dependent Kinase (CDK) inhibitor (IC50 values are 26, 3, 4, 216, 10, 200 and 13 nM for CDK1/B, CDK2/E, CDK2/A, CDK4/D, CDK5/p25, CDK7/H and CDK9/T, respectively). CGP60474 is a selective and ATP-competitive PKC inhibitor. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.71
HY-171932CaMKIIδ-IN-1 -
Similarity Score 0.60
HY-135750VAF347 -
Similarity Score 0.56
HY-179716JAK1/2 ligand 1 -
Similarity Score 0.55
HY-W013852PKC-IN-6 -
Similarity Score 0.55
HY-183131CaMKII-IN-4 -
Similarity Score 0.54
HY-153542AP-C6 -
Similarity Score 0.52
HY-180292Tubulin/VEGFR-2-IN-2 -
Similarity Score 0.52
HY-160688GW759710A -
Similarity Score 0.51
HY-757804-(2-(4-Morpholinophenylamino)pyrimidin-4-yl)benzoic acid -
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References
- [1]. Jorda R, et al. How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases?. J Med Chem. 2018;61(20):9105-9120. [Content Brief]
- [2]. Han HW, et al. LINCS L1000 dataset-based repositioning of CGP-60474 as a highly potent anti-endotoxemic agent. Sci Rep. 2018;8(1):14969. Published 2018 Oct 8. [Content Brief]
- [3]. Stanetty P, et al. Novel and efficient access to phenylamino-pyrimidine type protein kinase C inhibitors utilizing a Negishi cross-coupling strategy. J Org Chem. 2005;70(13):5215-5220. [Content Brief]
