1652591-80-4
1652591-80-4
Chemical Structure
GSK121
- CAS No.: 1652591-80-4
- Formula:C25H26F3N5O3
- Molecular Weight:501.50
IUPAC Name: (3-aminopiperidin-1-yl)(1-methyl-2-(1-methyl-1H-indol-2-yl)-1H-benzo[d]imidazol-5-yl)methanone 2,2,2-trifluoroacetate
InChIKey: CUCLWQZRCAQPJM-UHFFFAOYSA-N
SMILES: NC1CCCN(C1)C(C2=CC3=C(C=C2)N(C)C(C4=CC5=C(N4C)C=CC=C5)=N3)=O.OC(C(F)(F)F)=O
Biological Activity: GSK121 is a selective PAD4 inhibitor. GSK121 can be used in the research of PAD4-related diseases, including those characterized by abnormal NET levels and various tumors[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GSK121 | 99.81% | GSK121 is a selective PAD4 inhibitor. GSK121 can be used in the research of PAD4-related diseases, including those characterized by abnormal NET levels and various tumors. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.75
HY-120343GSK106 -
Similarity Score 0.66
HY-115676GSK199 analog hydrochloride -
Similarity Score 0.59
HY-103058GSK199 -
Similarity Score 0.59
HY-100514GSK484 hydrochloride -
Similarity Score 0.58
HY-123606GSK484 -
Similarity Score 0.55
HY-153450JBI-589 -
Similarity Score 0.52
HY-135304PAD-IN-2 -
Similarity Score 0.52
HY-176709GSK147 -
Similarity Score 0.51
HY-137655BMS-P5 -
Explore the MedChemAI to find more analogs
References
- [1]. Drewes G, et al. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. Nat Chem Biol. 2015 Mar;11(3):189-91. [Content Brief]
- [2]. Iaia S. Protein Arginine Deiminases: a novel mechanism of leukocyte trafficking under physiological and pathological conditions[J]. 2021.
