178685-33-1
Chemical Structure
Azide-PEG3-Tos
- CAS. Nr.: 178685-33-1
- Formula:C13H19N3O5S
- Molecular Weight:329.37
IUPAC Name: 2-(2-(2-azidoethoxy)ethoxy)ethyl 4-methylbenzenesulfonate
InChIKey: PTOJCKLTCKYNFG-UHFFFAOYSA-N
SMILES: [N-]=[N+]=NCCOCCOCCOS(C1=CC=C(C)C=C1)(=O)=O
Biological Activity: Azide-PEG3-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG3-Tos is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. Azide-PEG3-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Azide-PEG3-Tos | 99.91% | Azide-PEG3-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG3-Tos is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azide-PEG3-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | ||||||||||||||||||||
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References
- [1]. Borchmann DE, et al. GRGDS-Functionalized Poly(lactide)-graft-poly(ethylene glycol) Copolymers: Combining Thiol-Ene Chemistry with Staudinger Ligation. Macromolecules. 2013 Jun 11;46(11):4426-4431. [Content Brief]
- [2]. Park, Tae Kyo, et al. Compound bearing beta-galactoside-introduced self-immolative linker. WO2018124758A2.
