Tos-PEG2-O-Propargyl

Name: Tos-PEG2-O-Propargyl
Brand: MedChemExpress
SKU: HY-130162
Rating: 4.5 (1 reviews)

Cat. No.: HY-130162 Purity: 98.47%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Tos-PEG2-O-Propargyl is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458). Tos-PEG2-O-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Tos-PEG2-O-Propargyl Chemical Structure

CAS No. : 1119249-30-7

Size	Price	Stock	Quantity
5 mg	USD 45	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

Tos-PEG2-O-Propargyl is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458)^[1]. Tos-PEG2-O-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

298.35

Formula

C₁₄H₁₈O₅S

CAS No.

1119249-30-7

Appearance

Oil

Color

Light yellow to yellow

SMILES

C#CCOCCOCCOS(C1=CC=C(C)C=C1)(=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

Ethanol : 50 mg/mL (167.59 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3518 mL	16.7588 mL	33.5177 mL
5 mM	0.6704 mL	3.3518 mL	6.7035 mL
10 mM	0.3352 mL	1.6759 mL	3.3518 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.47%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (244 KB) HNMR (189 KB) LCMS (113 KB)

Handling Instructions (2659 KB)

References

[1]. Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol	1 mM	3.3518 mL	16.7588 mL	33.5177 mL	83.7942 mL
	5 mM	0.6704 mL	3.3518 mL	6.7035 mL	16.7588 mL
	10 mM	0.3352 mL	1.6759 mL	3.3518 mL	8.3794 mL
	15 mM	0.2235 mL	1.1173 mL	2.2345 mL	5.5863 mL
	20 mM	0.1676 mL	0.8379 mL	1.6759 mL	4.1897 mL
	25 mM	0.1341 mL	0.6704 mL	1.3407 mL	3.3518 mL
	30 mM	0.1117 mL	0.5586 mL	1.1173 mL	2.7931 mL
	40 mM	0.0838 mL	0.4190 mL	0.8379 mL	2.0949 mL
	50 mM	0.0670 mL	0.3352 mL	0.6704 mL	1.6759 mL
	60 mM	0.0559 mL	0.2793 mL	0.5586 mL	1.3966 mL
	80 mM	0.0419 mL	0.2095 mL	0.4190 mL	1.0474 mL
	100 mM	0.0335 mL	0.1676 mL	0.3352 mL	0.8379 mL