181632-25-7
Chemical Structure
SB 242084
- CAS No.: 181632-25-7
- Formula:C21H19ClN4O2
- Molecular Weight:394.85
IUPAC Name: 6-chloro-5-methyl-N-(6-((2-methylpyridin-3-yl)oxy)pyridin-3-yl)indoline-1-carboxamide
InChIKey: GIUZEIJUFOPTMR-UHFFFAOYSA-N
SMILES: O=C(N1CCC2=C1C=C(Cl)C(C)=C2)NC3=CC=C(OC4=CC=CN=C4C)N=C3
Biological Activity: SB 242084 is a selective, competitive and high-affinity (pKi=9.0) 5-HT2C receptor antagonist (crosses the blood-brain barrier). SB 242084 increases basal activity of dopaminergic neurons in the ventral tegmental area (VTA) of the midbrain and dopamine release in the vomeronasal nucleus. SB 242084 also increases mitochondrial gene expression and oxidative metabolism via 5-HT2A receptor. SB 242084 has good research potential in the negative symptoms of anxiety, depression and schizophrenia, as well as in acute organ damage[1][2][3].
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SB 242084 | 99.96% | SB 242084 is a selective, competitive and high-affinity (pKi=9.0) 5-HT2C receptor antagonist (crosses the blood-brain barrier). SB 242084 increases basal activity of dopaminergic neurons in the ventral tegmental area (VTA) of the midbrain and dopamine release in the vomeronasal nucleus. SB 242084 also increases mitochondrial gene expression and oxidative metabolism via 5-HT2A receptor. SB 242084 has good research potential in the negative symptoms of anxiety, depression and schizophrenia, as well as in acute organ damage. | ||||||||||||||||||||
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SB 242084 (Standard) | ≥98% | SB 242084 (Standard) is the analytical standard of SB 242084. This product is intended for research and analytical applications. SB 242084 is a selective, competitive and high-affinity (pKi=9.0) 5-HT2C receptor antagonist (crosses the blood-brain barrier). SB 242084 increases basal activity of dopaminergic neurons in the ventral tegmental area (VTA) of the midbrain and dopamine release in the vomeronasal nucleus. SB 242084 also increases mitochondrial gene expression and oxidative metabolism via 5-HT2A receptor. SB 242084 has good research potential in the negative symptoms of anxiety, depression and schizophrenia, as well as in acute organ damage. | ||||||||||||||||||||
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Similarity Score 0.98
HY-13409BSB 242084 monohydrochloride -
Similarity Score 0.98
HY-13409ASB 242084 dihydrochloride -
Similarity Score 0.82
HY-103112BSB 243213 -
Similarity Score 0.81
HY-103112SB 243213 hydrochloride -
Similarity Score 0.80
HY-103112ASB 243213 dihydrochloride -
Similarity Score 0.65
HY-18596SB-215505 -
Similarity Score 0.64
HY-19297SB-247853 -
Similarity Score 0.56
HY-103135SB 206553 hydrochloride -
Similarity Score 0.56
HY-132225SB 206553 -
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References
- [1]. Kennett GA, et al. SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology. 1997 Apr-May;36(4-5):609-20. [Content Brief]
- [2]. Harmon JL, et al. 5-HT2 Receptor Regulation of Mitochondrial Genes: Unexpected Pharmacological Effects of Agonists and Antagonists. J Pharmacol Exp Ther. 2016 Apr;357(1):1-9. [Content Brief]
