183499-57-2
183499-57-2
Chemical Structure
L-778123
- CAS No.: 183499-57-2
- Formula:C22H20ClN5O
- Molecular Weight:405.88
IUPAC Name: 4-((5-((4-(3-chlorophenyl)-3-oxopiperazin-1-yl)methyl)-1H-imidazol-1-yl)methyl)benzonitrile
InChIKey: JNUGFGAVPBYSHF-UHFFFAOYSA-N
SMILES: N#CC1=CC=C(CN2C(CN3CC(N(C4=CC=CC(Cl)=C4)CC3)=O)=CN=C2)C=C1
Biological Activity: L-778123 is a dual FPTase and GGPTase-I inhibitor, with IC50s of 2 nM and 98 nM respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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L-778123 | 99.92% | L-778123 is a dual FPTase and GGPTase-I inhibitor, with IC50s of 2 nM and 98 nM respectively. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.99
HY-16273AL-778123 hydrochloride -
Similarity Score 0.98
HY-16273BL-778123 dihydrochloride -
Similarity Score 0.74
HY-U00327Prenyl-IN-1 -
Similarity Score 0.57
HY-151566Antifungal agent 46 -
Similarity Score 0.55
HY-164064Anticancer agent 230 -
Similarity Score 0.51
HY-155493CYP19A1/CYP11B2-IN-1 -
Similarity Score 0.50
HY-147398Dopamine D4 receptor antagonist-1 -
Similarity Score 0.49
HY-164926PARP1-IN-33 -
Similarity Score 0.49
HY-177100Lotixparib -
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References
- [1]. Lobell RB, et al. Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I. Mol Cancer Ther. 2002 Jul;1(9):747-758. [Content Brief]
- [2]. Ghasemi S, et al. Comparison of Cytotoxic Activity of L778123 as a Farnesyltranferase Inhibitor and Doxorubicin against A549 and HT-29 Cell Lines. Adv Pharm Bull. 2013;3(1):73-77. [Content Brief]
