184877-64-3
Chemical Structure
Madindoline A
- CAS No.: 184877-64-3
- Formula:C22H27NO4
- Molecular Weight:369.45
InChIKey: XPVQXXLKOCZMGG-BHDDXSALSA-N
SMILES: O[C@@](C1=CC=CC=C12)(CCO3)[C@@]3([H])N2C[C@]4(C(C(CCCC)=C(C4=O)C)=O)C
Biological Activity: Madindoline A is an orally active gp130 antagonist with a KD of 288 μM. Madindoline A inhibits IL-6- and IL-11-induced osteoclastogenesis, suppresses IL-6-stimulated serum amyloid A protein production, inhibits bone resorption and bone loss, and also inhibits IL-6- and IL-11-dependent cell line growth, as well as IL-6-dependent Stat3 tyrosine phosphorylation. Madindoline A is applicable for the research of hormone-dependent postmenopausal osteoporosis[1][2].
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Madindoline A | Madindoline A is an orally active gp130 antagonist with a KD of 288 μM. Madindoline A inhibits IL-6- and IL-11-induced osteoclastogenesis, suppresses IL-6-stimulated serum amyloid A protein production, inhibits bone resorption and bone loss, and also inhibits IL-6- and IL-11-dependent cell line growth, as well as IL-6-dependent Stat3 tyrosine phosphorylation. Madindoline A is applicable for the research of hormone-dependent postmenopausal osteoporosis. | |||||||||||||||||||||
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- [1]. Hayashi M, et al. Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130. Proc Natl Acad Sci U S A. 2002;99(23):14728-14733. [Content Brief]
- [2]. Saleh AZ, et al. Binding of madindoline A to the extracellular domain of gp130. Biochemistry. 2005;44(32):10822-10827. [Content Brief]
Keywords
