1854061-16-7
1854061-16-7
Chemical Structure
PF-06649298
- CAS 番号: 1854061-16-7
- Formula:C16H22O5
- Molecular Weight:294.34
IUPAC Name: (R)-2-(4-(tert-butyl)phenethyl)-2-hydroxysuccinic acid
InChIKey: QNFWRHKLBLSSPB-MRXNPFEDSA-N
SMILES: O=C(O)[C@@](O)(CCC1=CC=C(C(C)(C)C)C=C1)CC(O)=O
Biological Activity: PF-06649298 is a sodium-coupled citrate transporter (NaCT or SLC13A5) inhibitor. PF-06649298 specifically interacts with NaCT with an IC50 value of 16.2 μM to inhibits the transport of citrate in human hepatocytes. PF-06649298 can be used for the research of regulating glucose metabolism and lipid metabolism[1][2].
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PF-06649298 | 98.32% | PF-06649298 is a sodium-coupled citrate transporter (NaCT or SLC13A5) inhibitor. PF-06649298 specifically interacts with NaCT with an IC50 value of 16.2 μM to inhibits the transport of citrate in human hepatocytes. PF-06649298 can be used for the research of regulating glucose metabolism and lipid metabolism. | ||||||||||||||||||||
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References
- [1]. Huard K, et al. Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family. J Med Chem. 2016 Feb 11;59(3):1165-75. [Content Brief]
- [2]. Huard K, et al. Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5). Sci Rep. 2015 Dec 1;5:17391. [Content Brief]
