18711-16-5
18711-16-5
Chemical Structure
NS309
- CAS No.: 18711-16-5
- Formula:C8H4Cl2N2O2
- Molecular Weight:231.04
IUPAC Name: (Z)-6,7-dichloro-3-(hydroxyimino)indolin-2-one
InChIKey: CVOUSAVHMDXCKG-UHFFFAOYSA-N
SMILES: O=C1NC2=C(C=CC(Cl)=C2Cl)/C1=N/O
Biological Activity: NS309 is a potent and selective activator of the Ca2+-activated SK/IK potassium channels, but displays no activity at BK channels[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NS309 | 99.09% | NS309 is a potent and selective activator of the Ca2+-activated SK/IK potassium channels, but displays no activity at BK channels. | ||||||||||||||||||||
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References
- [1]. Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons. [Content Brief]
- [2]. C Hougaard, et al. Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. Br J Pharmacol. 2007 Jul; 151(5): 655–665. [Content Brief]
- [3]. Nichole Coleman, et al. New Positive Ca2+-Activated K+ Channel Gating Modulators with Selectivity for KCa3.1. Mol Pharmacol. 2014 Sep; 86(3): 342–357. [Content Brief]
- [4]. Dorte Strøbaek, et al. Activation of human IK and SK Ca2+-activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime). Biochim Biophys Acta. 2004 Oct 11;1665(1-2):1-5. [Content Brief]
