188116-08-7
188116-08-7
Chemical Structure
ELB-139
- CAS No.: 188116-08-7
- Formula:C14H16ClN3O
- Molecular Weight:277.75
IUPAC Name: 1-(4-chlorophenyl)-4-(piperidin-1-yl)-1,5-dihydro-2H-imidazol-2-one
InChIKey: YGXIELIREXEJQN-UHFFFAOYSA-N
SMILES: O=C1N(C2=CC=C(Cl)C=C2)CC(N3CCCCC3)=N1
Biological Activity: ELB-139 is a progesterone analogue. ELB-139 is a GABAA receptor partial agonist. ELB-139 has anxiolytic and anticonvulsant activity. ELB-139 induces increase of extracellular 5-HT in the striatum and the medial prefrontal cortex of rats[1][2].
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ELB-139 | ELB-139 is a progesterone analogue. ELB-139 is a GABAA receptor partial agonist. ELB-139 has anxiolytic and anticonvulsant activity. ELB-139 induces increase of extracellular 5-HT in the striatum and the medial prefrontal cortex of rats. | |||||||||||||||||||||
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References
- [1]. Rabe H, et al. The novel anxiolytic ELB139 displays selectivity to recombinant GABA(A) receptors different from diazepam. Neuropharmacology. 2007 Mar;52(3):796-801. [Content Brief]
- [2]. Langen B, et al. ELB139 an agonist at the benzodiazepine binding site increases 5-HT in the striatum and prefrontal cortex of rats: a microdialysis study. Pharmacol Biochem Behav. 2007 Jan;86(1):79-85. [Content Brief]
Keywords
