2020052-55-3
2020052-55-3
Chemical Structure
CDK12-IN-E9
- CAS No.: 2020052-55-3
- Formula:C24H30N6O2
- Molecular Weight:434.53
IUPAC Name: (S)-N-(3-((3-ethyl-5-(2-(2-hydroxyethyl)piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)phenyl)acrylamide
InChIKey: CDCHESFKYUNJPV-FQEVSTJZSA-N
SMILES: C=CC(NC1=CC=CC(NC2=CC(N3[C@H](CCO)CCCC3)=NC4=C(CC)C=NN24)=C1)=O
Biological Activity: CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and a non-covalent CDK9 inhibitor, while avoiding ABC transporter-mediated efflux. CDK12-IN-E9 has weak binding ability to CDK7/CyclinH complex with an IC50> 1 μM[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CDK12-IN-E9 | 99.71% | CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and a non-covalent CDK9 inhibitor, while avoiding ABC transporter-mediated efflux. CDK12-IN-E9 has weak binding ability to CDK7/CyclinH complex with an IC50> 1 μM. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.67
HY-78428CDK-IN-6 -
Similarity Score 0.67
HY-10492RDinaciclib (Standard) -
Similarity Score 0.52
HY-139004SGC-CK2-1 -
Similarity Score 0.52
HY-12570CK2-IN-9 -
Similarity Score 0.51
HY-134912CMPPE -
Similarity Score 0.49
HY-158700DprE1-IN-10 -
Similarity Score 0.49
HY-119396DY3002 -
Similarity Score 0.48
HY-164476ES-072 -
Similarity Score 0.48
HY-162254EGFR/ACK1-IN-1 -
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