2036081-86-2
Chemical Structure
JNJ-55511118
- CAS No.: 2036081-86-2
- Formula:C14H8ClF3N2O2
- Molecular Weight:328.67
IUPAC Name: 5-(2-chloro-6-(trifluoromethoxy)phenyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
InChIKey: COBXSLRIXGQVGS-UHFFFAOYSA-N
SMILES: O=C1NC2=C(N1)C=C(C3=C(OC(F)(F)F)C=CC=C3Cl)C=C2
Biological Activity: JNJ-55511118 is a selective TARP γ-8 binding AMPA receptor modulator with oral bioavailability and blood-brain barrier permeability, with a Ki of 26 nM. JNJ-55511118 reduces voluntary intake of sweetened alcohol in male mice. In rodent models, JNJ-55511118 inhibits hippocampal neurotransmission, reduces specific electroencephalogram frequency bands, induces transient hyperlocomotion, impairs learning and memory abilities, and exerts anticonvulsant effects. JNJ-55511118 is applicable to research related to alcohol use disorder and seizures[1][2].
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JNJ-55511118 | 99.85% | JNJ-55511118 is a selective TARP γ-8 binding AMPA receptor modulator with oral bioavailability and blood-brain barrier permeability, with a Ki of 26 nM. JNJ-55511118 reduces voluntary intake of sweetened alcohol in male mice. In rodent models, JNJ-55511118 inhibits hippocampal neurotransmission, reduces specific electroencephalogram frequency bands, induces transient hyperlocomotion, impairs learning and memory abilities, and exerts anticonvulsant effects. JNJ-55511118 is applicable to research related to alcohol use disorder and seizures. | ||||||||||||||||||||
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- [1]. Hoffman JL, et al. Inhibition of AMPA receptors (AMPARs) containing transmembrane AMPAR regulatory protein γ-8 with JNJ-55511118 shows preclinical efficacy in reducing chronic repetitive alcohol self-administration. Alcohol Clin Exp Res. 2021;45(7):1424-1435. [Content Brief]
- [2]. Maher MP, et al. Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8. J Pharmacol Exp Ther. 2016;357(2):394-414. [Content Brief]
Keywords
