21085-60-9
Chemical Structure
Calcium mesoxalate
Synonym(s): Ketomalonic acid calcium; Mesoxalic acid calcium; Oxomalonic acid calcium
- CAS No.: 21085-60-9
- Formula:C3CaO5
- Molecular Weight:156.11
IUPAC Name: 1-bromo-3-isothiocyanatobenzene
InChIKey: YYJSBERANQTJJH-UHFFFAOYSA-L
SMILES: O=C(C([O-])=O)C([O-])=O.[Ca+2]
Biological Activity: Calcium mesoxalate (Ketomalonic acid calcium) is an orally active antidiabetic agent. Calcium mesoxalate increases pancreatic insulin content. Calcium mesoxalate reduces dietary hyperglycemia. Calcium mesoxalate inhibits Epinephrine-induced hyperglycemia in rabbits and exacerbates Alloxan (HY-116823)-induced hypoglycemic convulsions. Calcium mesoxalate exerts no antidiabetic effect in pancreatectomized dogs and fails to reduce the susceptibility of rabbits to Alloxan-induced diabetes. Calcium mesoxalate can be used in diabetes-related research[1][2][3][4].
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Calcium mesoxalate | Calcium mesoxalate (Ketomalonic acid calcium) is an orally active antidiabetic agent. Calcium mesoxalate increases pancreatic insulin content. Calcium mesoxalate reduces dietary hyperglycemia. Calcium mesoxalate inhibits Epinephrine-induced hyperglycemia in rabbits and exacerbates Alloxan (HY-116823)-induced hypoglycemic convulsions. Calcium mesoxalate exerts no antidiabetic effect in pancreatectomized dogs and fails to reduce the susceptibility of rabbits to Alloxan-induced diabetes. Calcium mesoxalate can be used in diabetes-related research. | |||||||||||||||||||||
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References
- [1]. Bernatchez JA, et al. Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase. The Journal of biological chemistry. 2015 Jan 16;290(3):1474-84. [Content Brief]
- [2]. Davis WR, et al. Inhibition of HIV-1 reverse transcriptase-catalyzed DNA strand transfer reactions by 4-chlorophenylhydrazone of mesoxalic acid. Biochemistry. 2000 Nov 21;39(46):14279-91. [Content Brief]
- [3]. TAKEUCHI S. Effect of mesoxalate on insulin content of pancreas. Endocrinol Jpn. 1958 Sep;5(3):177-84. [Content Brief]
- [4]. KOBAYASHI Y, et al. Mechanism of anti-diabetic activity of calcium mesoxalate[J]. The Japanese Journal of Pharmacology, 1955, 4(2): 103-110.
