213697-53-1
Chemical Structure
DavePhos
- CAS No.: 213697-53-1
- Formula:C26H36NP
- Molecular Weight:393.54
IUPAC Name: 2'-(dicyclohexylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine
InChIKey: ZEMZPXWZVTUONV-UHFFFAOYSA-N
SMILES: CN(C)C(C=CC=C1)=C1C2=C(P(C3CCCCC3)C4CCCCC4)C=CC=C2
Biological Activity: DavePhos is a phosphine ligand and electron donor. DavePhos can form cationic rhodium complexes to promote the selective hydrocarboxylation of styrene derivatives with CO2 and H2. As a sacrificial electron donor, DavePhos assists in generating active Rh-H species to initiate the catalytic cycle. DavePhos can be used in Buchwald−Hartwig cross-coupling reactions within palladium-based catalytic systems. DavePhos is applicable to platinum-catalyzed reductive amination of amine-acid[1][2][3].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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DavePhos | 98.0% | DavePhos is a phosphine ligand and electron donor. DavePhos can form cationic rhodium complexes to promote the selective hydrocarboxylation of styrene derivatives with CO2 and H2. As a sacrificial electron donor, DavePhos assists in generating active Rh-H species to initiate the catalytic cycle. DavePhos can be used in Buchwald−Hartwig cross-coupling reactions within palladium-based catalytic systems. DavePhos is applicable to platinum-catalyzed reductive amination of amine-acid. | ||||||||||||||||||||
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References
- [1]. Azzali E, et al. 2-Aminooxazole as a Novel Privileged Scaffold in Antitubercular Medicinal Chemistry. ACS Med Chem Lett. 2020 Jun 8;11(7):1435-1441.
- [2]. Jin Y, et al. Catalytic direct hydrocarboxylation of styrenes with CO and H. Nature communications. 2022 Dec 08;13(1):7584.
- [3]. Kao Y T, et al. A Direct‑to‑Biology Amine‑Acid Amination for Rapid Phenotypic Profiling of Lysosomotropic Natural Products. Journal of the American Chemical Society, 2026. doi:10.1021/jacs.6c06623
