2158266-58-9
Chemical Structure
GNE-207
- CAS No.: 2158266-58-9
- Formula:C29H30N6O3
- Molecular Weight:510.59
IUPAC Name: 5-(8-(5-acetyl-1-(tetrahydro-2H-pyran-4-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)isoquinolin-3-yl)-N-methylpicolinamide
InChIKey: MUJXZEDIWKGKQD-UHFFFAOYSA-N
SMILES: O=C(NC)C1=NC=C(C2=CC3=C(C=N2)C(C4=NN(C5CCOCC5)C6=C4CN(C(C)=O)CC6)=CC=C3)C=C1
Biological Activity: GNE-207 is a potent, selective and orally bioavailable inhibitor of the bromodomain of CBP, with an IC50 of 1 nM, exhibits a selectively index of >2500-fold against BRD4 (1). GNE-207 shows excellent CBP potency, with an EC50 of 18 nM for MYC expression in MV-4-11 cells[1].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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GNE-207 | 99.94% | GNE-207 is a potent, selective and orally bioavailable inhibitor of the bromodomain of CBP, with an IC50 of 1 nM, exhibits a selectively index of >2500-fold against BRD4 (1). GNE-207 shows excellent CBP potency, with an EC50 of 18 nM for MYC expression in MV-4-11 cells. | ||||||||||||||||||||
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-
Similarity Score 0.65
HY-154984JET-209 -
Similarity Score 0.64
HY-128761CBP/p300-IN-2 -
Similarity Score 0.54
HY-108435RGNE-049 (Standard) -
Similarity Score 0.53
HY-108696GNE-781 -
Similarity Score 0.53
HY-100726RGNE-272 (Standard) -
Similarity Score 0.52
HY-183817GNE-781-COOH -
Similarity Score 0.50
HY-153948CBP-IN-1 -
Similarity Score 0.50
HY-187066trans-CBP/p300 ligand 3-cyclohexane-CHO -
Similarity Score 0.49
HY-177927CBP-IN-1 acid -
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