2173992-60-2
Chemical Structure
UNC-2170 maleate
- CAS No.: 2173992-60-2
- Formula:C18H25BrN2O5
- Molecular Weight:429.31
IUPAC Name: 3-bromo-N-(3-(tert-butylamino)propyl)benzamide fumarate
InChIKey: WCAATDGMINWXPJ-WLHGVMLRSA-N
SMILES: O=C(NCCCNC(C)(C)C)C1=CC=CC(Br)=C1.O=C(O)/C=C/C(O)=O
Biological Activity: UNC-2170 maleate is the maleate salt form of UNC-2170 (HY-115531). UNC-2170 maleate is a selective inhibitor for the methyl-lysine binding protein 53BP1, with IC50 of 29 µM and Kd of 22 µM. UNC-2170 maleate shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB)[1].
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UNC-2170 maleate | UNC-2170 maleate is the maleate salt form of UNC-2170 (HY-115531). UNC-2170 maleate is a selective inhibitor for the methyl-lysine binding protein 53BP1, with IC50 of 29 µM and Kd of 22 µM. UNC-2170 maleate shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB). | |||||||||||||||||||||
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Keywords
