21945-37-9
Chemical Structure
(E)-MS0019266
- CAS No.: 21945-37-9
- Formula:C11H10N4
- Molecular Weight:198.22
IUPAC Name: (E)-2-((2-(pyridin-2-yl)hydrazono)methyl)pyridine
InChIKey: KYDLWVBNCQERCD-NTEUORMPSA-N
SMILES: C1(/C=N/NC2=NC=CC=C2)=NC=CC=C1
Biological Activity: (E)-MS0019266 is a potent inhibitor of DNA damage repair. (E)-MS0019266 inhibits ribonucleotide reductase by generating reactive oxygen species. (E)-MS0019266 also reduces expression of genes related to cell cycle arrest and mitosis, including polo-like kinase 1, kinesin family member 20a, cyclin B1 and aurora kinase A. (E)-MS0019266 is promising for research of inhibitors of ribonucleotide reductase and polo-like kinase 1[1].
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(E)-MS0019266 | (E)-MS0019266 is a potent inhibitor of DNA damage repair. (E)-MS0019266 inhibits ribonucleotide reductase by generating reactive oxygen species. (E)-MS0019266 also reduces expression of genes related to cell cycle arrest and mitosis, including polo-like kinase 1, kinesin family member 20a, cyclin B1 and aurora kinase A. (E)-MS0019266 is promising for research of inhibitors of ribonucleotide reductase and polo-like kinase 1. | |||||||||||||||||||||
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