2201048-82-8
Chemical Structure
Zagociguat
Synonym(s): CY-6463; IW-6463
- CAS No.: 2201048-82-8
- Formula:C16H10F4N6
- Molecular Weight:362.28
IUPAC Name: 8-(2-fluorobenzyl)-6-(5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl)imidazo[1,2-a]pyrazine
InChIKey: GTKNNCQKFKGSHR-UHFFFAOYSA-N
SMILES: FC1=C(CC2=NC(C3=NN=C(C(F)(F)F)N3)=CN4C=CN=C24)C=CC=C1
Biological Activity: Zagociguat (CY-6463) is an orally active and BBB-permeable soluble guanylate cyclase (sGC) stimulator. Zagociguat can increase cGMP levels, regulate blood pressure, improve neuronal function, reduce inflammatory responses, and exert neuroprotective and cognitive-improving effects. Zagociguat can be used in the research of neurodegenerative diseases[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Zagociguat | 99.09% | Zagociguat (CY-6463) is an orally active and BBB-permeable soluble guanylate cyclase (sGC) stimulator. Zagociguat can increase cGMP levels, regulate blood pressure, improve neuronal function, reduce inflammatory responses, and exert neuroprotective and cognitive-improving effects. Zagociguat can be used in the research of neurodegenerative diseases. | ||||||||||||||||||||
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References
- [1]. Correia SS, et al. The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases. Front Pharmacol. 2021 May 24;12:656561. [Content Brief]
- [2]. Debra J. Wallace, et al. Accelerated Development of a Scalable Synthesis of CY6463, a CNS-Penetrant sGC Stimulator for the Treatment of Neurodegenerative Diseases. Org Process Res Dev. 2021;25(10):2288-2299.
