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Cat. No.: HY-112864

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TGFβRI-IN-6

TGFβRI-IN-6 (compound 22) is a potent TGFβRI inhibitor with an IC₅₀ value of 0.55 nM. TGFβRI-IN-6 has the potential to enhance anti-tumor immunity.

For research use only. We do not sell to patients.

CAS No.: 2072051-04-6
Formula: C₁₇H₁₀F₄N₆
Molecular Weight:374.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

TGFβRI-IN-6 Chemical Structure

CAS No.: 2072051-04-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

TGFβRI-IN-6 (compound 22) is a potent TGFβRI inhibitor with an IC₅₀ value of 0.55 nM. TGFβRI-IN-6 has the potential to enhance anti-tumor immunity^[1].

All TGF-β Receptor Isoforms :

In Vitro

TGFβRI-IN-6 (compound 22) inhibits TGFβRI, with a K_i of 0.22 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2072051-04-6
Molecular Weight 374.30
Formula C₁₇H₁₀F₄N₆
SMILES

FC1=CN=CC=C1NC2=C(C=CN3)C3=NC(C4=NC(C(F)(F)F)=CC=C4)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Harikrishnan LS, et, al. Heterobicyclic inhibitors of transforming growth factor beta receptor I (TGFβRI). Bioorg Med Chem. 2018 Mar 1;26(5):1026-1034. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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TGFβRI-IN-6

All TGF-β Receptor Isoforms