220673-95-0
Chemical Structure
Antisauvagine-30
Synonym(s): aSvg-30
- CAS No.: 220673-95-0
- Formula:C161H274N48O46S
- Molecular Weight:3650.26
SMILES: O=C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCSC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@@H](C)CC)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@@H](CC2=CC=CC=C2)N
Biological Activity: Antisauvagine-30 (aSvg-30) is a selective peptide antagonist of the CRF2 receptor, with an IC50 of 1.1 nM for mouse CRF2. Antisauvagine-30 modulates cAMP signaling, gastric emptying, food intake, fear conditioning, anxiety-like behavior, stress responses, corticosterone levels, c-Fos expression, and CRF expression. Antisauvagine-30 is used in studies of anxiety-related disorders[1][2][3][4][5][6][7].
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Antisauvagine-30 | 99.74% | Antisauvagine-30 (aSvg-30) is a selective peptide antagonist of the CRF2 receptor, with an IC50 of 1.1 nM for mouse CRF2. Antisauvagine-30 modulates cAMP signaling, gastric emptying, food intake, fear conditioning, anxiety-like behavior, stress responses, corticosterone levels, c-Fos expression, and CRF expression. Antisauvagine-30 is used in studies of anxiety-related disorders. | ||||||||||||||||||||
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References
- [1]. Rivier J, et al. Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonists. Journal of medicinal chemistry. 2002 Oct 10;45(21):4737-47. [Content Brief]
- [2]. Zorrilla EP, et al. Anxiolytic-like effects of antisauvagine-30 in mice are not mediated by CRF2 receptors. PloS one. 2013;8(8):e63942.
- [3]. Skórzewska A, et al. The effect of CRF2 receptor antagonists on rat conditioned fear responses and c-Fos and CRF expression in the brain limbic structures. Behavioural brain research. 2011 Aug 01;221(1):155-65.
- [4]. Rühmann A, et al. Structural requirements for peptidic antagonists of the corticotropin-releasing factor receptor (CRFR): development of CRFR2beta-selective antisauvagine-30. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15264-9.
- [5]. Wang L, et al. Peripheral urocortin inhibits gastric emptying and food intake in mice: differential role of CRF receptor 2. American journal of physiology. Regulatory, integrative and comparative physiology. 2001 Nov;281(5):R1401-10.
- [6]. Radulovic J, et al. Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1999 Jun 15;19(12):5016-25. [Content Brief]
- [7]. Mackay KB, et al. Effects of a selective agonist and antagonist of CRF2 receptors on cardiovascular function in the rat. European journal of pharmacology. 2003 May 23;469(1-3):111-5. [Content Brief]
