2227392-55-2
2227392-55-2
Chemical Structure
BSJ-01-175
- CAS No.: 2227392-55-2
- Formula:C30H33ClN6O2
- Molecular Weight:545.08
IUPAC Name: (E)-N-(4-(((1R,3R)-3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)cyclohexyl)oxy)phenyl)-4-(dimethylamino)but-2-enamide
InChIKey: DMUSMYYDKCXFKR-MRJIRHQNSA-N
SMILES: ClC1=CN=C(N[C@H]2C[C@@H](CCC2)OC3=CC=C(C=C3)NC(/C=C/CN(C)C)=O)N=C1C4=CNC5=CC=CC=C45
Biological Activity: BSJ-01-175 is a potent and selective CDK12/13 covalent inhibitor. BSJ-01-175 demonstrates exquisite selectivity, potent inhibition of RNA polymerase II phosphorylation, and downregulation of CDK12-targeted genes in cancer cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BSJ-01-175 | 99.88% | BSJ-01-175 is a potent and selective CDK12/13 covalent inhibitor. BSJ-01-175 demonstrates exquisite selectivity, potent inhibition of RNA polymerase II phosphorylation, and downregulation of CDK12-targeted genes in cancer cells. | ||||||||||||||||||||
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Structural Analogs
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Similarity Score 0.74
HY-103618THZ531 -
Similarity Score 0.69
HY-128587Mevociclib -
Similarity Score 0.66
HY-80013THZ1 -
Similarity Score 0.65
HY-80013B(E/Z)-THZ1 dihydrochloride -
Similarity Score 0.64
HY-12280THZ2 -
Similarity Score 0.63
HY-164553ZSQ836 -
Similarity Score 0.59
HY-19988THZ1-R -
Similarity Score 0.57
HY-13984NT-1 -
Similarity Score 0.57
HY-15609AZD-3463 -
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