223472-31-9
Chemical Structure
ONO-4817
- CAS No.: 223472-31-9
- Formula:C22H28N2O6
- Molecular Weight:416.47
IUPAC Name: N-((2S,4S)-1-(ethoxymethoxy)-5-(hydroxyamino)-4-methyl-5-oxopentan-2-yl)-4-phenoxybenzamide
InChIKey: HDWWQELUBWGQGA-WMZOPIPTSA-N
SMILES: ONC([C@@H](C)C[C@@H](COCOCC)NC(C(C=C1)=CC=C1OC2=CC=CC=C2)=O)=O
Biological Activity: ONO-4817 is a potent inhibitor of matrix metalloproteinase (MMP). Inhibition of matrix metalloproteinases (MMPs) is expected to suppress atherosclerotic neointimal proliferation and thus limits atheromatous plaque progression. ONO-4817 suppresses the development of aortic intimal hyperplasia in experimental hyperlipidemic rabbit[1].
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ONO-4817 | 98.80% | ONO-4817 is a potent inhibitor of matrix metalloproteinase (MMP). Inhibition of matrix metalloproteinases (MMPs) is expected to suppress atherosclerotic neointimal proliferation and thus limits atheromatous plaque progression. ONO-4817 suppresses the development of aortic intimal hyperplasia in experimental hyperlipidemic rabbit. | ||||||||||||||||||||
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Keywords
