2242957-52-2
2242957-52-2
Chemical Structure
UCB-J
- CAS No.: 2242957-52-2
- Formula:C17H15F3N2O
- Molecular Weight:320.31
IUPAC Name: (R)-1-((3-methylpyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one
InChIKey: RFSDYRVOGWHOFT-ZDUSSCGKSA-N
SMILES: O=C1C[C@@](C2=CC(F)=C(C(F)=C2)F)([H])CN1CC3=CC=NC=C3C
Biological Activity: UCB-J is a ligand for synaptic vesicle protein 2A (SV2A) with pIC50 values for human and rat SV2A of 8.15 and 7.6 respectively. UCB-J can be used to display and quantify the total synaptic density throughout the brain[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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UCB-J | 99.62% | UCB-J is a ligand for synaptic vesicle protein 2A (SV2A) with pIC50 values for human and rat SV2A of 8.15 and 7.6 respectively. UCB-J can be used to display and quantify the total synaptic density throughout the brain. | ||||||||||||||||||||
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References
- [1]. Aline Delva, et al. Loss of Presynaptic Terminal Integrity in the Substantia Nigra in Early Parkinson's Disease. Mov Disord. 2020 Aug 7. [Content Brief]
- [2]. Nabeel B Nabulsi, et al. Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain. J Nucl Med. 2016 May;57(5):777-84. [Content Brief]
- [3]. Zhengxin Cai, et al. Synthesis and Preclinical Evaluation of an 18 F-Labeled Synaptic Vesicle Glycoprotein 2A PET Imaging Probe: [ 18 F]SynVesT-2. ACS Chem Neurosci. 2020 Feb 19;11(4):592-603. [Content Brief]
