2244451-48-5
2244451-48-5
Chemical Structure
BI-4916
- CAS No.: 2244451-48-5
- Formula:C23H24Cl2N2O6S
- Molecular Weight:527.42
IUPAC Name: ethyl (S)-2-((4-(1-(4,5-dichloro-1,6-dimethyl-1H-indole-2-carboxamido)-2-hydroxyethyl)phenyl)sulfonyl)acetate
InChIKey: HCDAVCLCBXIYPW-QGZVFWFLSA-N
SMILES: O=C(OCC)CS(=O)(C1=CC=C([C@H](NC(C(N2C)=CC3=C2C=C(C)C(Cl)=C3Cl)=O)CO)C=C1)=O
Biological Activity: BI-4916 is a proagent of BI-4924. BI-4924 is a NADH/NAD+-competitive PHGDH inhibitor. BI-4916 inhibits cancer cell migration. BI-4916 can be used for cancer, inflammation and infection study[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BI-4916 | 98.67% | BI-4916 is a proagent of BI-4924. BI-4924 is a NADH/NAD+-competitive PHGDH inhibitor. BI-4916 inhibits cancer cell migration. BI-4916 can be used for cancer, inflammation and infection study. | ||||||||||||||||||||
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References
- [1]. Weinstabl H, et al. Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor BI-4924 Disrupts Serine Biosynthesis. J Med Chem. 2019 Jul 31. [Content Brief]
- [2]. Kiweler N, et al. Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis. Nat Commun. 2022 May 16;13(1):2699. [Content Brief]
- [3]. Becker B, et al. Serine metabolism is crucial for cGAS-STING signaling and viral defense control in the gut. iScience. 2024 Feb 8;27(3):109173. [Content Brief]
