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Cat. No.: HY-132900

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RORγ agonist 1

RORγ agonist 1 is a potent and orally bioavailable RORγ agonist (EC₅₀ = 21 nM) with antitumor activity.

For research use only. We do not sell to patients.

CAS No.: 2260631-91-0
Formula: C₂₉H₂₇ClF₄N₂O₄S
Molecular Weight:611.05

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

RORγ agonist 1 Chemical Structure

CAS No.: 2260631-91-0

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Sample (0.1mg)

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

RORγ agonist 1 is a potent and orally bioavailable RORγ agonist (EC₅₀ = 21 nM) with antitumor activity.

All ROR Isoforms :

Chemical Information

CAS No. 2260631-91-0
Molecular Weight 611.05
Formula C₂₉H₂₇ClF₄N₂O₄S
SMILES

FCCN1C2=CC=C(C(N[C@H](C3=CC=C(C=C3)S(CC)(=O)=O)CO)=O)C=C2C=C1CC4=C(C=C(C=C4)Cl)C(F)(F)F
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lu B, et al. Discovery of 2-(Ortho-Substituted Benzyl)-Indole Derivatives as Potent and Orally Bioavailable RORγ Agonists with Antitumor Activity. J Med Chem. 2021 Oct 28;64(20):14983-14996. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Chemical Information
Purity & Documentation
References

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